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Hiroaki Shimokawa Selected Research

Cardiovascular Diseases (Cardiovascular Disease)

3/2023Beneficial Effects of Low-Intensity Pulsed Ultrasound Therapy on Right Ventricular Dysfunction in Animal Models.
1/2023Plasma ANGPTL8 Levels and Risk for Secondary Cardiovascular Events in Japanese Patients With Stable Coronary Artery Disease Receiving Statin Therapy.
1/2022Impact of statins in patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association.
1/2022A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk.
8/2020The impact of antiplatelet therapy on patients with vasospastic angina: A multicenter registry study of the Japanese Coronary Spasm Association.
8/2020Nitric oxide and endothelium-dependent hyperpolarization mediated by hydrogen peroxide in health and disease.
1/2020Prognosis and risk stratification in cardiac sarcoidosis patients with preserved left ventricular ejection fraction.
11/2019Coronary Functional Abnormalities in Patients With Angina and Nonobstructive Coronary Artery Disease.
1/2019Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease.
1/2019Important roles of endothelial caveolin-1 in endothelium-dependent hyperpolarization and ischemic angiogenesis in mice.
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Hiroaki Shimokawa Research Topics

Disease

71Heart Failure
03/2024 - 03/2002
49Cardiovascular Diseases (Cardiovascular Disease)
03/2023 - 03/2002
45Myocardial Infarction
12/2022 - 05/2004
41Pulmonary Hypertension
01/2021 - 07/2002
40Myocardial Ischemia (Ischemic Heart Diseases)
12/2023 - 01/2002
31Coronary Artery Disease (Coronary Atherosclerosis)
08/2023 - 01/2002
31Inflammation (Inflammations)
01/2023 - 02/2002
28Spasm (Spasms)
02/2022 - 02/2002
28Hypertension (High Blood Pressure)
01/2022 - 04/2002
26Stroke (Strokes)
12/2022 - 02/2002
24Hypoxia (Hypoxemia)
01/2021 - 07/2002
23Coronary Vasospasm (Coronary Artery Vasospasm)
01/2023 - 03/2002
21Ischemia
09/2021 - 07/2003
21Pulmonary Arterial Hypertension
01/2021 - 01/2005
20Fibrosis (Cirrhosis)
01/2021 - 02/2002
19Shock
01/2022 - 11/2004
17Arteriosclerosis
01/2016 - 02/2002
15Thrombosis (Thrombus)
01/2022 - 04/2002
15Atherosclerosis
10/2018 - 03/2002
14Atrial Fibrillation
11/2023 - 12/2016
11Reperfusion Injury
01/2016 - 08/2004
10Neoplasms (Cancer)
12/2023 - 11/2010
10Hemorrhage
06/2023 - 02/2008
10Hypertrophy
01/2021 - 10/2003
10Cardiomyopathies (Cardiomyopathy)
01/2021 - 05/2002
9Unstable Angina
11/2023 - 01/2016
9Angina Pectoris
01/2023 - 01/2005
9Chest Pain (Chest Pains)
01/2023 - 03/2002
8Pathologic Constriction (Stenosis)
01/2022 - 04/2002
8Ventricular Tachycardia
12/2021 - 01/2015
8Diabetes Mellitus
01/2020 - 10/2004
7Cognitive Dysfunction
05/2024 - 01/2017
7Ventricular Remodeling
01/2018 - 05/2004
7Vascular Remodeling
01/2018 - 12/2002
7Vascular Diseases (Vascular Disease)
11/2010 - 02/2002
6Death (Near-Death Experience)
01/2022 - 09/2010
6Cardiac Sudden Death (Sudden Cardiac Arrest)
12/2021 - 05/2004
6Cardiomegaly (Heart Hypertrophy)
05/2016 - 01/2005
5Alzheimer Disease (Alzheimer's Disease)
05/2024 - 09/2018
5Stable Angina
01/2023 - 01/2005
5Tachycardia (Tachyarrhythmias)
01/2023 - 05/2007
5Acute Coronary Syndrome
11/2021 - 04/2002
5Ischemic Stroke
09/2021 - 12/2016
5Embolism (Embolus)
09/2021 - 12/2016
5Atherosclerotic Plaque (Atheroma)
12/2020 - 04/2002
5Infarction (Infarctions)
01/2018 - 07/2004
5Right Ventricular Hypertrophy
06/2014 - 02/2004
4Microvascular Angina (Cardiac Syndrome X)
12/2022 - 01/2003
4Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
10/2022 - 09/2018
4Ventricular Fibrillation
12/2021 - 04/2009
4Coronary Stenosis (Coronary Artery Stenosis)
01/2021 - 03/2003

Drug/Important Bio-Agent (IBA)

80rho-Associated KinasesIBA
01/2023 - 02/2002
29fasudil (AT 877)IBA
12/2019 - 04/2002
25Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2023 - 02/2002
19Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
03/2024 - 07/2003
17Proteins (Proteins, Gene)FDA Link
03/2024 - 07/2002
17Vasodilator Agents (Vasodilators)IBA
01/2023 - 07/2003
17Acetylcholine (Acetylcholine Chloride)FDA Link
02/2022 - 03/2002
14Brain Natriuretic Peptide (Natrecor)FDA Link
03/2024 - 09/2008
14Biomarkers (Surrogate Marker)IBA
01/2023 - 05/2008
13Nitric Oxide Synthase (NO Synthase)IBA
11/2023 - 02/2004
13omega-Chloroacetophenone (Mace)IBA
01/2023 - 09/2010
12Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
05/2024 - 02/2002
10CytokinesIBA
03/2024 - 05/2002
10Protein Isoforms (Isoforms)IBA
11/2023 - 07/2005
10LipidsIBA
08/2023 - 09/2010
10Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2019 - 07/2003
10hydroxyfasudilIBA
02/2016 - 02/2002
10Angiotensin IIIBA
05/2015 - 02/2002
10Monomeric GTP-Binding ProteinsIBA
01/2015 - 02/2002
9MonocrotalineIBA
01/2021 - 02/2004
9NitratesIBA
08/2020 - 10/2004
9Reactive Oxygen Species (Oxygen Radicals)IBA
08/2020 - 02/2003
8Cyclophilin AIBA
01/2021 - 11/2010
7RivaroxabanIBA
11/2023 - 12/2016
7pitavastatin (itavastatin)FDA Link
08/2023 - 01/2018
7LDL CholesterolIBA
08/2023 - 09/2010
7Calcium Channel Blockers (Blockers, Calcium Channel)IBA
01/2023 - 10/2004
7Lactic Acid (Lactate)FDA LinkGeneric
01/2021 - 03/2002
6Messenger RNA (mRNA)IBA
11/2023 - 07/2002
6CreatinineIBA
01/2021 - 09/2004
6ErythropoietinFDA Link
10/2011 - 03/2006
5Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
03/2024 - 03/2009
5pro-brain natriuretic peptide (1-76)IBA
03/2024 - 01/2019
5AnticoagulantsIBA
12/2023 - 11/2008
5Angiotensin Receptor AntagonistsIBA
01/2022 - 07/2013
5Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
08/2020 - 09/2006
5Serotonin (5 Hydroxytryptamine)IBA
02/2017 - 02/2002
5endothelium-dependent hyperpolarization factor (EDHF)IBA
01/2015 - 05/2005
4LDL Receptors (LDL Receptor)IBA
01/2021 - 09/2010

Therapy/Procedure

78Therapeutics
05/2024 - 09/2002
20Extracorporeal Shockwave Therapy
07/2023 - 11/2004
16Percutaneous Coronary Intervention
06/2023 - 01/2005
10Stents
03/2020 - 04/2002
9Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
02/2022 - 04/2009
6Catheter Ablation
06/2021 - 01/2015
6Ligation
01/2019 - 12/2002
5Drug-Eluting Stents
01/2021 - 01/2012
5Coronary Artery Bypass (Coronary Artery Bypass Surgery)
10/2011 - 09/2004
4Secondary Prevention
02/2022 - 02/2012